產品名稱：26S Proteasome Regulatory Subunit 6B (PSMC4) Antibody (Biotin)

26S Proteasome Regulatory Subunit 6B (PSMC4) Antibody (Biotin) is a Rabbit Polyclonal against 26S Proteasome Regulatory Subunit 6B (PSMC4) conjugated to Biotin. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Target	26S Proteasome Regulatory Subunit 6B (PSMC4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA
Host	Rabbit
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Biotin
Immunogen	Recombinant Human 26S protease regulatory subunit 6B protein (112-181AA).
Isotype	IgG
Form	Liquid
Purity	> 95%
Purification	Purified by Protein G.
Storage	Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P43686 (UniProt, ExPASy)
UniProt Secondary AC	Q96FV5, Q9UBM3, Q9UEX3
UniProt Entry Name	PRS6B_HUMAN
Gene Symbol	PSMC4
GeneID	5704
OMIM	602707
NCBI Accession	NP_006494.1 NM_006503.3 NP_694546.1 NM_153001.2
HGNC	9551
KEGG	hsa:5704
Ensembl	ENSG00000013275
String	9606.ENSP00000157812
Buffer	0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Regulatory Subunit 6B (PSMC4)