產品名稱：26S Proteasome Regulatory Subunit 7 (PSMC2) Antibody

26S Proteasome Regulatory Subunit 7 (PSMC2) Antibody is a Rabbit Polyclonal antibody against 26S Proteasome Regulatory Subunit 7 (PSMC2). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Target	26S Proteasome Regulatory Subunit 7 (PSMC2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Human PSMC2.
Isotype	IgG
Form	Liquid
Purification	Antigen Affinity Chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P35998 (UniProt, ExPASy)
UniProt Secondary AC	A4D0Q1, B7Z5E2, Q3LIA5, Q9UDI3
UniProt Entry Name	PRS7_HUMAN
Gene Symbol	PSMC2
GeneID	5701
OMIM	154365
NCBI Accession	NP_001191382.1 NM_001204453.1 NP_002794.1 NM_002803.3
HGNC	9548
KEGG	hsa:5701
Ensembl	ENSG00000161057
String	9606.ENSP00000391211
Buffer	PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Regulatory Subunit 7 (PSMC2)