產品詳情
簡單介紹：
ACK1 (pY518) Antibody
詳情介紹：
ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP) stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
Research Articles on ACK1 (pY518)
| Target | ACK1 (pY518) |
| Clonality | Polyclonal |
| Target Modification | Tyr518 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, DB |
| Host | Rabbit |
| Recommended dilutions | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y518 of human ACK1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q07912 (UniProt, ExPASy) |
| UniProt Secondary AC | Q6ZMQ0, Q8N6U7, Q96H59 |
| UniProt Entry Name | ACK1_HUMAN |
| KEGG | hsa:10188 |
| String | 9606.ENSP00000371341 |
| Molecular Weight | Calculated MW: 115 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Cow TNK2. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |
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