產品名稱：Activin A Receptor Type 2A (ACVR2A) Antibody

ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

Target	Activin A Receptor Type 2A (ACVR2A)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 2-29 amino acids from the N-terminal region of human ACVR2A.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P27037 (UniProt, ExPASy)
UniProt Secondary AC	B2RAB8, B4DWQ2, D3DP85, Q53TH4, Q6NWV2, Q92474
UniProt Entry Name	AVR2A_HUMAN
NCBI Accession	NP_001265508.1 NP_001265509.1 NP_001607.1
KEGG	hsa:92
String	9606.ENSP00000241416
Molecular Weight	Calculated MW: 57.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat, Cow, Chicken and Sheep ACVR2A.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Activin A Receptor Type 2A (ACVR2A)