產品詳情
簡單介紹：
Anti-FLNB antibody (STJA0008150)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Filamin-B is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FLNB |
| Gene ID: | 2317 |
| Uniprot ID: | FLNB_HUMAN |
| Specificity: | This antibody detects endogenous levels of FLNB at Human |
| Immunogen: | Synthesized peptide derived from human FLNB |
| Post Translational Modifications | ISGylation prevents ability to interact with the upstream activators of the JNK cascade and inhibits IFNA-induced JNK signaling. Ubiquitination by a SCF-like complex containing ASB2 isoform 1 leads to proteasomal degradation which promotes muscle differentiation. |
| Function | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| Protein Name | Filamin-B Fln-B Abp-278 Abp-280 Homolog Actin-Binding-Like Protein Beta-Filamin Filamin Homolog 1 Fh1 Filamin-3 Thyroid Autoantigen Truncated Actin-Binding Protein Truncated Abp |
| Database Links | Reactome: R-HSA-1169408 |
| Cellular Localisation | Isoform 1: Cytoplasm Cell Cortex Cytoplasm Cytoskeleton Stress Fiber Myofibril Sarcomere Z Line In Differentiating Myotubes Isoform 1 Isoform 2 And Isoform 3 Are Localized Diffusely Throughout The Cytoplasm With Regions Of Enrichment At The Longitudinal Actin Stress Fiber In Differentiated Tubes Isoform 1 Is Also Detected Within The Z-Lines Isoform 2: Cytoplasm Isoform 3: Cytoplasm Isoform 6: Cytoplasm Polarized At The Periphery Of Myotubes |
| Alternative Antibody Names | Anti-Filamin-B antibody Anti-Fln-B antibody Anti-Abp-278 antibody Anti-Abp-280 Homolog antibody Anti-Actin-Binding-Like Protein antibody Anti-Beta-Filamin antibody Anti-Filamin Homolog 1 antibody Anti-Fh1 antibody Anti-Filamin-3 antibody Anti-Thyroid Autoantigen antibody Anti-Truncated Actin-Binding Protein antibody Anti-Truncated Abp antibody Anti-FLNB antibody Anti-FLN1L antibody Anti-FLN3 antibody Anti-TABP antibody Anti-TAP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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