產品詳情
簡單介紹：
ACE2 protein (hFc) (STJP000155)
詳情介紹：
| Host: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | ACE2-hFc protein was developed from human and has a target region of hFc. For use in research applications. |
| Formulation: | 1. PBS pH 7.4, 2. 20 mM Na-citrate, 150 mM NaCl; pH 6.0 |
| Purification: | Purified by Protein A affinity chromatography following gel filtration. Protein is sterile-filtrated through 0.22 µm filter. NA |
| Concentration: | 1 mg/ml |
| Storage Instruction: | Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles |
| Gene Symbol: | ACE2 |
| Gene ID: | 59272 |
| Uniprot ID: | ACE2_HUMAN |
| Immunogen Region: | 18-740 aa |
| Immunogen: | cDNA encodes Angiotensin-converting enzyme 2.Protein contains amino acids 18-740 and human IgG1 Fc in C-terminus. |
| Post Translational Modifications | N-glycosylation on Asn-90 may limit SARS infectivity. Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1. Phosphorylated. Phosphorylation at Tyr-781 probably inhibits interaction with AP2M1 and enables interactions with proteins containing SH2 domains. |
| Function | Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins (apelin-13, Pyr1apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency. In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity. (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. Isoform 2: Non-functional as a carboxypeptidase. Isoform 2: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2. |
| Protein Name | Angiotensin-Converting Enzyme 2 Angiotensin-Converting Enzyme Homolog Aceh Angiotensin-Converting Enzyme-Related Carboxypeptidase Ace-Related Carboxypeptidase Metalloprotease Mprot15 Cleaved Into - Processed Angiotensin-Converting Enzyme 2 |
| Database Links | Reactome: R-HSA-2022377 Reactome: R-HSA-9678110 Reactome: R-HSA-9679191 Reactome: R-HSA-9694614 Reactome: R-HSA-9733458 |
| Cellular Localisation | Processed Angiotensin-Converting Enzyme 2: Secreted Cell Membrane Single-Pass Type I Membrane Protein Cytoplasm Cell Projection Cilium Apical Cell Membrane Detected In Both Cell Membrane And Cytoplasm In Neurons Isoform 2: Apical Cell Membrane |
| Alternative Protein Names | Angiotensin-Converting Enzyme 2 protein Angiotensin-Converting Enzyme Homolog protein Aceh protein Angiotensin-Converting Enzyme-Related Carboxypeptidase protein Ace-Related Carboxypeptidase protein Metalloprotease Mprot15 Cleaved Into - Processed Angiotensin-Converting Enzyme 2 protein ACE2 protein UNQ868 protein PRO1885 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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