產品詳情
簡單介紹:
5HT1B Blocking Peptide for STJ500004 peptide (STJ503613)
詳情介紹:
Applications: | Immunodepletion/Immunocompetition |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | 5HT1B Blocking Peptide for STJ500004 is synthetically produced from the 160-260 sequence and is suitable for use in western blot applications. |
Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | Htr1b |
Gene ID: | 15551 |
Uniprot ID: | 5HT1B_MOUSE |
Immunogen Region: | 160-260 |
Specificity: | This blocking peptide is recommended for use in combination with 5HT1B antibody, STJ500004 |
Immunogen: | Synthetic peptide taken within amino acid region 160-260 on rat 5HT1B |
Tissue Specificity | Predominantly expressed in striatum and Purkinje cells. |
Post Translational Modifications | Phosphorylated. Palmitoylated. |
Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. |
Peptide Name | 5-Hydroxytryptamine Receptor 1b 5-Ht-1b 5-Ht1b Serotonin Receptor 1b |
Database Links | Reactome: R-MMU-390666 Reactome: -MMU-418594 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
Alternative Peptide Names | 5-Hydroxytryptamine Receptor 1b protein 5-Ht-1b protein 5-Ht1b protein Serotonin Receptor 1b protein Htr1b protein 5ht1b protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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