產品詳情
簡單介紹：
Anti-ABCC10 antibody (835-884) (STJ94207)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ATP-binding cassette sub-family C member 10 (835-884) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-p 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCC10 |
| Gene ID: | 89845 |
| Uniprot ID: | MRP7_HUMAN |
| Immunogen Region: | 835-884 |
| Specificity: | MRP7 Polyclonal Antibody detects endogenous levels of MRP7 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human MRP7. AA range:835-884 |
| Tissue Specificity | In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells, moderately in the adluminal compartment of the seminiferous tubules, and in vascular endothelial cells. Isoform 1: Specifically expressed in spleen. Isoform 2: Widely expressed. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel. Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 10 Multidrug Resistance-Associated Protein 7 |
| Database Links | Reactome: R-HSA-382556 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Basal Cell Membrane Localized To The Basal Membrane Of Sertoli Cells |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 10 antibody Anti-Multidrug Resistance-Associated Protein 7 antibody Anti-ABCC10 antibody Anti-MRP7 antibody Anti-SIMRP7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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