產品詳情
簡單介紹：
FPGS protein (Recombinant) (STJ11104141)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Recombinant-FPGS-protein was developed from rabbit. For use in research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S4141RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:100-1:500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FPGS |
| Gene ID: | 2356 |
| Uniprot ID: | FOLC_HUMAN |
| Immunogen Region: | 450-587 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-587 of human FPGS (Q05932). |
| Immunogen Sequence: | NADQQNFTVTLDQVLLRCLE HQQHWNHLDEEQASPDLWSA PSPEPGGSASLLLAPHPPHT CSASSLVFSCISHALQWISQ GRDPIFQPPSPPKGLLTHPV AHSGASILREAAAIHVLVTG SLHLVGGVLKLLEPALSQ |
| Function | Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. |
| Protein Name | Folylpolyglutamate Synthase - Mitochondrial Folylpoly-Gamma-Glutamate Synthetase Fpgs Tetrahydrofolylpolyglutamate Synthase Tetrahydrofolate Synthase |
| Database Links | Reactome: R-HSA-196757 |
| Cellular Localisation | Isoform 1: Mitochondrion Inner Membrane Mitochondrion Matrix Isoform 2: Cytoplasm |
| Alternative Protein Names | Folylpolyglutamate Synthase - Mitochondrial protein Folylpoly-Gamma-Glutamate Synthetase protein Fpgs protein Tetrahydrofolylpolyglutamate Synthase protein Tetrahydrofolate Synthase protein FPGS protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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