Human Activin RIIB/ACVR2B protein (Recombinant) (C-hFc & His) (STJP002586) STJP002586|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human Activin RIIB/ACVR2B protein (Recombinant) (C-hFc & His) (STJP002586)
產品型號：STJP002586
產品廠商：ST john's laboratory
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Human Activin RIIB/ACVR2B protein (Recombinant) (C-hFc & His) (STJP002586)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human Activin RIIB/ACVR2B-C-hFc & His protein was developed from hek293 cells and has a target region of C-hFc & His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	1.Measured by its binding ability in a functional ELISA.Immobilized Human ACVR2B at 1 Mu g/mL (100 Mu L/well) can bind Human BMPRIA with a linear range of 0.5-62.5 ng/mL.2.Measured by its binding ability in a functional ELISA.Immobilized Human CD105

Gene Symbol:	ACVR2B
Gene ID:	93
Uniprot ID:	AVR2B_HUMAN
Immunogen Region:	Ser19-Thr134
Immunogen:	Recombinant Human Activin RIIB/ACVR2B Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser19-Thr134) of human ACVR2B/Activin RIIB (Accession #NP_001097.2) fused with an Fc, 6×His tag at the C-termi

Function	Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.
Protein Name	Activin Receptor Type-2b Activin Receptor Type Iib Actr-Iib
Database Links	Reactome: R-HSA-1181150 Reactome: R-HSA-1433617 Reactome: R-HSA-1502540 Reactome: R-HSA-201451
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Activin Receptor Type-2b protein Activin Receptor Type Iib protein Actr-Iib protein ACVR2B protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human Activin RIIB/ACVR2B protein (Recombinant) (C-hFc &amp; His) (STJP002586)

產品名稱：Human Activin RIIB/ACVR2B protein (Recombinant) (C-hFc & His) (STJP002586)