Human ADAM15 protein (Recombinant) (STJP000603) STJP000603|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human ADAM15 protein (Recombinant) (STJP000603)
產品型號：STJP000603
產品廠商：ST john's laboratory
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Human ADAM15 protein (Recombinant) (STJP000603)

詳情介紹：

Host:	HEK293
Note:	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human ADAM15-protein was developed from hek293. For use in research applications.

Conjugation:	Unconjugated
Formulation:	Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Dilution Range:	Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction:	Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin:	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA

Gene Symbol:	ADAM15
Gene ID:	8751
Uniprot ID:	ADA15_HUMAN
Immunogen Region:	ASP207-THR696
Immunogen:	Optimized DNA sequence encoding extracellular domain of human Disintegrin and metalloproteinase 15-ADAM15 (ASP207-THR696) including a C-terminal His tag was expressed in HEK293 cells. NA

Tissue Specificity	Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells.
Post Translational Modifications	The precursor is cleaved by a furin endopeptidase. Phosphorylation increases association with PTKs.
Function	Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
Protein Name	Disintegrin And Metalloproteinase Domain-Containing Protein 15 Adam 15 Metalloprotease Rgd Disintegrin Protein Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15 Mdc-15 Metargidin
Database Links	Reactome: R-HSA-1474228 Reactome: R-HSA-8941237
Cellular Localisation	Endomembrane System Single-Pass Type I Membrane Protein Cell Junction Adherens Junction Cell Projection Cilium Flagellum Cytoplasmic Vesicle Secretory Vesicle Acrosome The Majority Of The Protein Is Localized In A Perinuclear Compartment Which May Correspond To The Trans-Golgi Network Or The Late Endosome The Pro-Protein Is The Major Detectable Form On The Cell Surface Whereas The Majority Of The Protein In The Cell Is Processed
Alternative Protein Names	Disintegrin And Metalloproteinase Domain-Containing Protein 15 protein Adam 15 protein Metalloprotease Rgd Disintegrin Protein protein Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15 protein Mdc-15 protein Metargidin protein ADAM15 protein MDC15 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human ADAM15 protein (Recombinant) (STJP000603)