ATG16L1 Blocking Peptide for STJ500180 peptide (STJ505494) STJ505494-250|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：ATG16L1 Blocking Peptide for STJ500180 peptide (STJ505494)
產品型號：STJ505494-250
產品廠商：ST john's laboratory
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簡單介紹：

ATG16L1 Blocking Peptide for STJ500180 peptide (STJ505494)

詳情介紹：

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	ATG16L1 Blocking Peptide for STJ500180 is synthetically produced from the 560-610 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	ATG16L1
Gene ID:	55054
Uniprot ID:	A16L1_HUMAN
Immunogen Region:	560-610
Specificity:	This blocking peptide is recommended for use in combination with ATG16L1 antibody, STJ500180
Immunogen:	Synthetic peptide taken within amino acid region 560-610 on human Autophagy-related protein 16-1.

Post Translational Modifications	Proteolytic cleavage by activated CASP3 leads to degradation and may regulate autophagy upon cellular stress and apoptotic stimuli. Phosphorylation at Ser-139 promotes association with the ATG12-ATG5 conjugate to form the ATG12-ATG5-ATG16L1 complex.
Function	Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling. During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8. Thereby, controls the elongation of the nascent autophagosomal membrane. Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8. Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2. Plays a role in regulating morphology and function of Paneth cell.
Peptide Name	Autophagy-Related Protein 16-1 Apg16-Like 1
Database Links	Reactome: R-HSA-1632852
Cellular Localisation	Cytoplasm Preautophagosomal Structure Membrane Peripheral Membrane Protein Endosome Membrane Lysosome Membrane Recruited To Omegasomes Membranes By Wipi2 Omegasomes Are Endoplasmic Reticulum Connected Strutures At The Origin Of Preautophagosomal Structures Localized To Preautophagosomal Structure (Pas) Where It Is Involved In The Membrane Targeting Of Atg5 Localizes Also To Discrete Punctae Along The Ciliary Axoneme Upon Activation Of Non-Canonical Autophagy Recruited To Single-Membrane Endolysosomal Compartments
Alternative Peptide Names	Autophagy-Related Protein 16-1 protein Apg16-Like 1 protein ATG16L1 protein APG16L protein UNQ9393 protein PRO34307 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：ATG16L1 Blocking Peptide for STJ500180 peptide (STJ505494)