Anti-ABCC4 antibody (1067-1325) (STJ22460) STJ22460|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-ABCC4 antibody (1067-1325) (STJ22460)
產品型號：STJ22460
產品廠商：ST john's laboratory
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簡單介紹：

Anti-ABCC4 antibody (1067-1325) (STJ22460)

詳情介紹：

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-MRP4/ABCC4 (1067-1325) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ABCC4
Gene ID:	10257
Uniprot ID:	MRP4_HUMAN
Immunogen Region:	1067-1325
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1067-1325 of human MRP4/ABCC4 (NP_005836.2).
Immunogen Sequence:	SQEKVGIVGRTGAGKSSLIS ALFRLSEPEGKIWIDKILTT EIGLHDLRKKMSIIPQEPVL FTGTMRKNLDPFNEHTDEEL WNALQEVQLKETIEDLPGKM DTELAESGSNFSVGQRQLVC LARAILRKNQILIIDEATAN VDPRTDELIQKKIREKFAHC TVLTIAHRLNTIIDSDKIMV LDSGRLKEYDEPYVLLQNKE SLFYKMVQQLGKAEAAALTE TAKQVYFKRNYPHIGHTDH

Tissue Specificity	Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. sinusoidal membrane of hepatocytes.
Post Translational Modifications	N-glycosylated.leading to substrate-selective effects on its transport activity.
Function	ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate.
Protein Name	Atp-Binding Cassette Sub-Family C Member 4 Mrp/Cmoat-Related Abc Transporter Multi-Specific Organic Anion Transporter B Moat-B Multidrug Resistance-Associated Protein 4
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-382556 Reactome: R-HSA-9748787 Reactome: R-HSA-9753281
Cellular Localisation	Basolateral Cell Membrane Multi-Pass Membrane Protein Apical Cell Membrane Its Localization To The Basolateral Or Apical Membranes Is Tissue-Dependent
Alternative Antibody Names	Anti-Atp-Binding Cassette Sub-Family C Member 4 antibody Anti-Mrp/Cmoat-Related Abc Transporter antibody Anti-Multi-Specific Organic Anion Transporter B antibody Anti-Moat-B antibody Anti-Multidrug Resistance-Associated Protein 4 antibody Anti-ABCC4 antibody Anti-MOATB antibody Anti-MRP4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ABCC4 antibody (1067-1325) (STJ22460)