產品詳情
簡單介紹：
Anti-ABCC4 antibody (1067-1325) [S4887RM] (STJ11104887)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-Atp-Binding Cassette Sub-Family C Member 4 (1067-1325) is suitable for use in Western Blot research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S4887RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCC4 |
| Gene ID: | 10257 |
| Uniprot ID: | MRP4_HUMAN |
| Immunogen Region: | 1067-1325 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1067-1325 of human MRP4/ABCC4. (NP_005836.2). |
| Tissue Specificity | Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. sinusoidal membrane of hepatocytes. |
| Post Translational Modifications | N-glycosylated.leading to substrate-selective effects on its transport activity. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 4 Mrp/Cmoat-Related Abc Transporter Multi-Specific Organic Anion Transporter B Moat-B Multidrug Resistance-Associated Protein 4 |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-382556 Reactome: R-HSA-9748787 Reactome: R-HSA-9753281 |
| Cellular Localisation | Basolateral Cell Membrane Multi-Pass Membrane Protein Apical Cell Membrane Its Localization To The Basolateral Or Apical Membranes Is Tissue-Dependent |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 4 antibody Anti-Mrp/Cmoat-Related Abc Transporter antibody Anti-Multi-Specific Organic Anion Transporter B antibody Anti-Moat-B antibody Anti-Multidrug Resistance-Associated Protein 4 antibody Anti-ABCC4 antibody Anti-MOATB antibody Anti-MRP4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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