產品詳情
簡單介紹：
Anti-ABCC6 antibody (290-370 aa) (STJ190991)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ATP-binding cassette sub-family C member 6 (290-370 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCC6 |
| Gene ID: | 368 |
| Uniprot ID: | MRP6_HUMAN |
| Immunogen Region: | 290-370 aa |
| Specificity: | MRP6 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 290-370 |
| Post Translational Modifications | Glycosylated. |
| Function | Isoform 1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin. Isoform 1: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 6 Anthracycline Resistance-Associated Protein Multi-Specific Organic Anion Transporter E Moat-E Multidrug Resistance-Associated Protein 6 |
| Database Links | Reactome: R-HSA-382556 Reactome: R-HSA-5690338 |
| Cellular Localisation | Basal Cell Membrane Multi-Pass Membrane Protein Localized To The Basal Membrane Of Sertoli Cells Isoform 1: Basolateral Cell Membrane Isoform 2: Endoplasmic Reticulum Membrane Single-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 6 antibody Anti-Anthracycline Resistance-Associated Protein antibody Anti-Multi-Specific Organic Anion Transporter E antibody Anti-Moat-E antibody Anti-Multidrug Resistance-Associated Protein 6 antibody Anti-ABCC6 antibody Anti-ARA antibody Anti-MRP6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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