產品詳情
簡單介紹：
Anti-ABCD1 antibody (650-745) [S5156RM] (STJ11105156)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-Atp-Binding Cassette Sub-Family D Member 1 (650-745) is suitable for use in Western Blot research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S5156RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCD1 |
| Gene ID: | 215 |
| Uniprot ID: | ABCD1_HUMAN |
| Immunogen Region: | 650-745 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 650-745 of human ABCD1/ALD (NP_000024.2). |
| Immunogen Sequence: | AGIALLSITHRPSLWKYHTH LLQFDGEGGWKFEKLDSAAR LSLTEEKQRLEQQLAGIPKM QRRLQELCQILGEAVAPAHV PAPSPQGPGGLQGAST |
| Post Translational Modifications | Tyrosine-phosphorylated. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosesynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes.namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs. |
| Protein Name | Atp-Binding Cassette Sub-Family D Member 1 Adrenoleukodystrophy Protein Aldp |
| Database Links | Reactome: R-HSA-1369062 Reactome: R-HSA-2046105 Reactome: R-HSA-2046106 Reactome: R-HSA-390247 Reactome: R-HSA-5684045 Reactome: R-HSA-9603798 |
| Cellular Localisation | Peroxisome Membrane Multi-Pass Membrane Protein Mitochondrion Membrane Lysosome Membrane Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family D Member 1 antibody Anti-Adrenoleukodystrophy Protein antibody Anti-Aldp antibody Anti-ABCD1 antibody Anti-ALD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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