Anti-ABCE1/RNase L antibody (N-Term) (STJ71645) STJ71645-100|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-ABCE1/RNase L antibody (N-Term) (STJ71645)
產品型號：STJ71645-100
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

Anti-ABCE1/RNase L antibody (N-Term) (STJ71645)

詳情介紹：

Host:	Goat
Applications:	Pep-ELISA/WB/IF/FC
Reactivity:	Human/Mouse/Rat/Dog/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-ABCE1/RNase L (N-Term) is suitable for use in ELISA, Western Blot, Immunofluorescence and Flow Cytometry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	ELISA-antibody detection limit dilution 1:32000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	ABCE1
Gene ID:	6059
Uniprot ID:	ABCE1_HUMAN
Immunogen Region:	N-Term
Accession Number:	NP_002931.2; NP_001035809.1
Specificity:	Reported variants represent identical protein: NP_002931.2 NP_001035809.1
Immunogen Sequence:	NHDKCKPKKCRQEC

Function	Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly. Able to hydrolyze ATP, GTP, UTP and CTP. Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits. Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage.this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy. RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL. Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway. (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections.
Protein Name	Atp-Binding Cassette Sub-Family E Member 1 2'-5'-Oligoadenylate-Binding Protein Huhp68 Rnase L Inhibitor Ribonuclease 4 Inhibitor Rns4i
Database Links	Reactome: R-HSA-8983711 Reactome: R-HSA-909733
Cellular Localisation	Cytoplasm Mitochondrion
Alternative Antibody Names	Anti-Atp-Binding Cassette Sub-Family E Member 1 antibody Anti-2'-5'-Oligoadenylate-Binding Protein antibody Anti-Huhp68 antibody Anti-Rnase L Inhibitor antibody Anti-Ribonuclease 4 Inhibitor antibody Anti-Rns4i antibody Anti-ABCE1 antibody Anti-RLI antibody Anti-RNASEL1 antibody Anti-RNASELI antibody Anti-RNS4I antibody Anti-OK antibody Anti-SW-cl.40 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ABCE1/RNase L antibody (N-Term) (STJ71645)