Human ALK-4/ACVR1B protein (Recombinant) (C-hFc & his) (STJP002553) STJP002553|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human ALK-4/ACVR1B protein (Recombinant) (C-hFc & his) (STJP002553)
產品型號：STJP002553
產品廠商：ST john's laboratory
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Human ALK-4/ACVR1B protein (Recombinant) (C-hFc & his) (STJP002553)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human ALK-4/ACVR1B-C-hFc & his protein was developed from hek293 cells and has a target region of C-hFc & his. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Human ACVR1B at 0.5 Mu g/mL (100 Mu L/well) can bind Human ACVR2B with a linear range of 2.0-286.1 ng/mL.

Gene Symbol:	ACVR1B
Gene ID:	91
Uniprot ID:	ACV1B_HUMAN
Immunogen Region:	Met 1-Glu 126
Immunogen:	Recombinant Human ALK-4/ACVR1B Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met 1-Glu 126) of human ACVR1B (Accession #NP_004293.1) fused with a C-hFc＆his at the C-terminus.

Post Translational Modifications	Autophosphorylated. Phosphorylated by activin receptor type-2 (ACVR2A or ACVR2B) in response to activin-binding at serine and threonine residues in the GS domain. Phosphorylation of ACVR1B by activin receptor type-2 regulates association with SMAD7. Ubiquitinated. Level of ubiquitination is regulated by the SMAD7-SMURF1 complex. Ubiquitinated.
Function	Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
Protein Name	Activin Receptor Type-1b Activin Receptor Type Ib Actr-Ib Activin Receptor-Like Kinase 4 Alk-4 Serine/Threonine-Protein Kinase Receptor R2 Skr2
Database Links	Reactome: R-HSA-1181150 Reactome: R-HSA-1433617 Reactome: R-HSA-1502540
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Activin Receptor Type-1b protein Activin Receptor Type Ib protein Actr-Ib protein Activin Receptor-Like Kinase 4 protein Alk-4 protein Serine/Threonine-Protein Kinase Receptor R2 protein Skr2 protein ACVR1B protein ACVRLK4 protein ALK4 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human ALK-4/ACVR1B protein (Recombinant) (C-hFc &amp; his) (STJP002553)

產品名稱：Human ALK-4/ACVR1B protein (Recombinant) (C-hFc & his) (STJP002553)