Human alpha 1 antitrypsin protein (Recombinant) (STJP000304) STJP000304|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human alpha 1 antitrypsin protein (Recombinant) (STJP000304)
產品型號：STJP000304
產品廠商：ST john's laboratory
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Human alpha 1 antitrypsin protein (Recombinant) (STJP000304)

詳情介紹：

Host:	HEK293
Note:	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human alpha 1 antitrypsin-protein was developed from hek293. For use in research applications.

Conjugation:	Unconjugated
Formulation:	Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Dilution Range:	Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction:	Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin:	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Immunoreactivity:	The activity was tested by the ability to inhibit trypsin cleavage of a fluorogenic peptide substrate Mca-RPKPVE-Nval-WRKDnp-NH2, with a calculated ED50 < 4.5nM NA

Gene Symbol:	SERPINA1
Gene ID:	5265
Uniprot ID:	A1AT_HUMAN
Immunogen Region:	GLU25-LYS418
Immunogen:	Optimized DNA sequence encoding mature chain of human alpha 1 antitrypsin-A1AT (GLU25-LYS418) including a C-terminal His tag was expressed in HEK293 cells. NA

Tissue Specificity	Ubiquitous. Expressed in leukocytes and plasma.
Post Translational Modifications	N-glycosylated. Differential glycosylation produces a number of isoforms. N-linked glycan at Asn-107 is alternatively di-antennary, tri-antennary or tetra-antennary. The glycan at Asn-70 is di-antennary with trace amounts of tri-antennary. Glycan at Asn-271 is exclusively di-antennary. Structure of glycans at Asn-70 and Asn-271 is Hex5HexNAc4. The structure of the antennae is Neu5Ac(alpha1-6)Gal(beta1-4)GlcNAc attached to the core structure Man(alpha1-6)Man(alpha1-3)Man(beta1-4)GlcNAc(beta1-4)GlcNAc. Some antennae are fucosylated, which forms a Lewis-X determinant. Proteolytic processing may yield the truncated form that ranges from Asp-30 to Lys-418. (Microbial infection) Proteolytically processed by Staphylococcus aureus seryl, cysteinyl, and metallo-proteases.
Function	Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Short peptide from AAT: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
Protein Name	Alpha-1-Antitrypsin Alpha-1 Protease Inhibitor Alpha-1-Antiproteinase Serpin A1 Cleaved Into - Short Peptide From Aat Spaat
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-204005 Reactome: R-HSA-381426 Reactome: R-HSA-5694530 Reactome: R-HSA-6798695 Reactome: R-HSA-8957275
Cellular Localisation	Secreted Endoplasmic Reticulum The S And Z Allele Are Not Secreted Effectively And Accumulate Intracellularly In The Endoplasmic Reticulum Short Peptide From Aat: Secreted Extracellular Space Extracellular Matrix
Alternative Protein Names	Alpha-1-Antitrypsin protein Alpha-1 Protease Inhibitor protein Alpha-1-Antiproteinase protein Serpin A1 Cleaved Into - Short Peptide From Aat protein Spaat protein SERPINA1 protein AAT protein PI protein PRO0684 protein PRO2209 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human alpha 1 antitrypsin protein (Recombinant) (STJP000304)