Human Angiopoietin-1/ANG-1/ANGPT1 protein (Recombinant) (C-His) (STJP001989) STJP001989|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human Angiopoietin-1/ANG-1/ANGPT1 protein (Recombinant) (C-His) (STJP001989)
產品型號：STJP001989
產品廠商：ST john's laboratory
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簡單介紹：

Human Angiopoietin-1/ANG-1/ANGPT1 protein (Recombinant) (C-His) (STJP001989)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human Angiopoietin-1/ANG-1/ANGPT1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ANGPT1
Gene ID:	284
Uniprot ID:	ANGP1_HUMAN
Immunogen Region:	Arg277-Phe498
Immunogen:	Recombinant Human Angiopoietin-1/ANG-1/ANGPT1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg277-Phe498) of human Angiopoietin-1/ANG-1/ANGPT1 (Accession #NP_001137.2) fused with a 6×His tag at

Function	Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
Protein Name	Angiopoietin-1 Ang-1
Database Links	Reactome: R-HSA-210993 Reactome: R-HSA-5673001
Cellular Localisation	Secreted
Alternative Protein Names	Angiopoietin-1 protein Ang-1 protein ANGPT1 protein KIAA0003 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human Angiopoietin-1/ANG-1/ANGPT1 protein (Recombinant) (C-His) (STJP001989)