Human Angiotensinogen protein (Recombinant) (STJP001867) STJP001867|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human Angiotensinogen protein (Recombinant) (STJP001867)
產品型號：STJP001867
產品廠商：ST john's laboratory
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Human Angiotensinogen protein (Recombinant) (STJP001867)

詳情介紹：

Host:	HEK293
Note:	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human Angiotensinogen-protein was developed from hek293. For use in research applications.

Conjugation:	Unconjugated
Formulation:	Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Dilution Range:	Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction:	Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin:	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA

Gene Symbol:	AGT
Gene ID:	183
Uniprot ID:	ANGT_HUMAN
Immunogen Region:	Asp34-Ala485
Immunogen:	Optimized DNA sequence encoding mature chain of human Angiotensinogen-AGT (Asp34-Ala485) including an N-terminal His tag was expressed in HEK293 cells. NA

Tissue Specificity	Expressed by the liver and secreted in plasma.
Post Translational Modifications	Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor. In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.
Function	Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor. Angiotensin-3: Stimulates aldosterone release. Angiotensin 1-7: Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
Protein Name	Angiotensinogen Serpin A8 Cleaved Into - Angiotensin-1 Angiotensin 1-10 Angiotensin I Ang I - Angiotensin-2 Angiotensin 1-8 Angiotensin Ii Ang Ii - Angiotensin-3 Angiotensin 2-8 Angiotensin Iii Ang Iii Des-Asp1-Angiotensin Ii - Angiotensin-4 Angiotensin 3-8 Angiotensin Iv Ang Iv - Angiotensin 1-9 - Angiotensin 1-7 - Angiotensin 1-5 - Angiotensin 1-4
Database Links	Reactome: R-HSA-1989781 Reactome: R-HSA-2022377 Reactome: R-HSA-375276 Reactome: R-HSA-416476 Reactome: R-HSA-418594
Cellular Localisation	Secreted
Alternative Protein Names	Angiotensinogen protein Serpin A8 Cleaved Into - Angiotensin-1 protein Angiotensin 1-10 protein Angiotensin I protein Ang I - Angiotensin-2 protein Angiotensin 1-8 protein Angiotensin Ii protein Ang Ii - Angiotensin-3 protein Angiotensin 2-8 protein Angiotensin Iii protein Ang Iii protein Des-Asp1-Angiotensin Ii - Angiotensin-4 protein Angiotensin 3-8 protein Angiotensin Iv protein Ang Iv - Angiotensin 1-9 - Angiotensin 1-7 - Angiotensin 1-5 - Angiotensin 1-4 protein AGT protein SERPINA8 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human Angiotensinogen protein (Recombinant) (STJP001867)