Human Asparaginyl endopeptidase/Legumain protein (Recombinant) (C-His) (STJP002513) STJP002513-50|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human Asparaginyl endopeptidase/Legumain protein (Recombinant) (C-His) (STJP002513)
產品型號：STJP002513-50
產品廠商：ST john's laboratory
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簡單介紹：

Human Asparaginyl endopeptidase/Legumain protein (Recombinant) (C-His) (STJP002513)

詳情介紹：

Host:	Mammalian
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human Asparaginyl endopeptidase/Legumain-C-His protein was developed from mammalian and has a target region of C-His. For use in research applications.

Formulation:	Supplied as a 0.2 Mu m filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 10% Glycerol, pH 8.0.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	LGMN
Gene ID:	5641
Uniprot ID:	LGMN_HUMAN
Immunogen Region:	Ile18-Tyr433
Immunogen:	Recombinant Human Asparaginyl endopeptidase/Legumain Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Ile18-Tyr433) of human Legumain (Accession #AAH03061.1) fused with His tag at the C-terminus.

Post Translational Modifications	Activated by autocatalytic processing at pH 4.
Function	Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocations in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.
Protein Name	Legumain Asparaginyl Endopeptidase Aep Protease - Cysteine 1
Database Links	Reactome: R-HSA-1679131 Reactome: R-HSA-196791 Reactome: R-HSA-2132295
Cellular Localisation	Lysosome
Alternative Protein Names	Legumain protein Asparaginyl Endopeptidase protein Aep protein Protease - Cysteine 1 protein LGMN protein PRSC1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human Asparaginyl endopeptidase/Legumain protein (Recombinant) (C-His) (STJP002513)