Human Autotaxin/E-NPP2 protein (Recombinant) (C-His) (STJP002054) STJP002054|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

所在位置: 首頁> 產品目錄> S類> ST john's laboratory>

查看大圖

產品名稱：Human Autotaxin/E-NPP2 protein (Recombinant) (C-His) (STJP002054)
產品型號：STJP002054
產品廠商：ST john's laboratory
產品文檔：

你添加了1件商品查看購物車

簡單介紹：

Human Autotaxin/E-NPP2 protein (Recombinant) (C-His) (STJP002054)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human Autotaxin/E-NPP2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.2 Mu m filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ENPP2
Gene ID:	5168
Uniprot ID:	ENPP2_HUMAN
Immunogen Region:	Ala36-Ile863
Immunogen:	Recombinant Human Autotaxin/E-NPP2 Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Ala36-Ile863) of human ENPP-2 (Accession #AAH34961.1) fused with a 6xHis tag at the C-terminus.

Post Translational Modifications	N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity. The interdomain disulfide bond between Cys-414 and Cys-806 is essential for catalytic activity.
Function	Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor. Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids. Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF).
Protein Name	Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2 E-Npp 2 Autotaxin Extracellular Lysophospholipase D Lysopld
Database Links	Reactome: R-HSA-199220
Cellular Localisation	Secreted
Alternative Protein Names	Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2 protein E-Npp 2 protein Autotaxin protein Extracellular Lysophospholipase D protein Lysopld protein ENPP2 protein ATX protein PDNP2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

姓名：

電話：

您的需求：

產品名稱：Human Autotaxin/E-NPP2 protein (Recombinant) (C-His) (STJP002054)