Anti-ABI2 antibody (100-200) (STJ117190) STJ117190|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-ABI2 antibody (100-200) (STJ117190)
產品型號：STJ117190
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

Anti-ABI2 antibody (100-200) (STJ117190)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ABI2 (100-200) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ABI2
Gene ID:	10152
Uniprot ID:	ABI2_HUMAN
Immunogen Region:	100-200
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ABI2 (NP_001269854.1).
Immunogen Sequence:	HKEKVARREIGILTTNKNTS RTHKIIAPANLERPVRYIRK PIDYTILDDIGHGVKWLLRF KVSTQNMKMGGLPRTTPPTQ KPPSPPMSGKGTLGRHSPYR T

Tissue Specificity	Widely expressed. Abundant in testes, ovary, thymus, and colon, with lower but detectable levels in prostate, peripheral blood leukocytes, and spleen.
Post Translational Modifications	Phosphorylated by ABL1.
Function	Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodsia formation. Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge. Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain. In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth. Participates in ocular lens morphogenesis, likely by regulating lamellipodsia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface. Also required for nascent adherens junction assembly in epithelial cells.
Protein Name	Abl Interactor 2 Abelson Interactor 2 Abi-2 Abl-Binding Protein 3 Ablbp3 Arg-Binding Protein 1 Argbp1
Database Links	Reactome: R-HSA-2029482 Reactome: R-HSA-4420097 Reactome: R-HSA-5663213 Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013423 Reactome: R-HSA-9664422
Cellular Localisation	Cytoplasm Nucleus Isoform 1: Cell Projection Lamellipodsium Cell Projection Filopodium Cytoskeleton Cell Junction Adherens Junction Isoform 1 But Not Isoform 3 Is Localized To Protruding Lamellipodsia And Filopodia Tips Present At Nascent Adherens Junctions Where It Clusters Adjacent To The Tips Of F-Actin Protrusions
Alternative Antibody Names	Anti-Abl Interactor 2 antibody Anti-Abelson Interactor 2 antibody Anti-Abi-2 antibody Anti-Abl-Binding Protein 3 antibody Anti-Ablbp3 antibody Anti-Arg-Binding Protein 1 antibody Anti-Argbp1 antibody Anti-ABI2 antibody Anti-ARGBPIA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ABI2 antibody (100-200) (STJ117190)