Human B7-H1/PD-L1/CD274 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002201) STJP002201-100|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human B7-H1/PD-L1/CD274 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002201)
產品型號：STJP002201-100
產品廠商：ST john's laboratory
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Human B7-H1/PD-L1/CD274 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002201)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human B7-H1/PD-L1/CD274-C-His & Avi protein was developed from hek293 cells and has a target region of C-His & Avi. For use in research applications.

Conjugation:	Biotin
Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	Immobilized Biotinylated Human PD-L1 at 0.5 Mu g/mL (100 Mu L/Well). Dose response curve for Anti-PD-L1 Ab with the EC50 of 11.3 ng/mL determined by ELISA.

Gene Symbol:	CD274
Gene ID:	29126
Uniprot ID:	PD1L1_HUMAN
Immunogen Region:	Phe19-Arg238
Immunogen:	Biotinylated Recombinant Human PD-L1 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Phe19-Arg238) of Human PD-L1 fused with His tag and Avi tag at the C-terminal.

Post Translational Modifications	Ubiquitinated.STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation. Ubiquitinated by MARCHF8.leading to degradation.
Function	Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.
Protein Name	Programmed Cell Death 1 Ligand 1 Pd-L1 Pdcd1 Ligand 1 Programmed Death Ligand 1 Hpd-L1 B7 Homolog 1 B7-H1 Cd Antigen Cd274
Database Links	Reactome: R-HSA-389948 Reactome: R-HSA-9701898
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Early Endosome Membrane Recycling Endosome Membrane Nucleus Associates With Cmtm6 At Recycling Endosomes Where It Is Protected From Being Targeted For Lysosomal Degradation Translocates To The Nucleus In Response To Hypoxia Via Its Interaction With Phosphorylated Stat3 Isoform 1: Cell Membrane Isoform 2: Endomembrane System Isoform 4: Secreted
Alternative Protein Names	Programmed Cell Death 1 Ligand 1 protein Pd-L1 protein Pdcd1 Ligand 1 protein Programmed Death Ligand 1 protein Hpd-L1 protein B7 Homolog 1 protein B7-H1 protein Cd Antigen Cd274 protein CD274 protein B7H1 protein PDCD1L1 protein PDCD1LG1 protein PDL1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human B7-H1/PD-L1/CD274 protein (Recombinant) (C-His &amp; Avi) {Biotin} (STJP002201)

產品名稱：Human B7-H1/PD-L1/CD274 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002201)