Human B7-H4/VTCN1 protein (Recombinant) (C-His) (STJP000989) STJP000989|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Human B7-H4/VTCN1 protein (Recombinant) (C-His) (STJP000989)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human B7-H4/VTCN1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Mouse B7-H4/VTCN1/VISTA at 1 Mu g/mL (100 Mu L/well) can bind B7-H4/VTCN1 Rabbit pAb with a linear range of 0.2-22 ng/mL.

Gene Symbol:	VTCN1
Gene ID:	79679
Uniprot ID:	VTCN1_HUMAN
Immunogen:	Recombinant Human B7-H4/VTCN1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe29-Ala258) of human B7-H4/B7S1/B7x (Accession #NP_078902.2) fused with a 6×His tag at the C-terminus.

Tissue Specificity	Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
Post Translational Modifications	N-glycosylated.
Function	Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Protein Name	V-Set Domain-Containing T-Cell Activation Inhibitor 1 B7 Homolog 4 B7-H4 B7h.5 Immune Costimulatory Protein B7-H4 Protein B7s1 T-Cell Costimulatory Molecule B7x
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Expressed At The Cell Surface A Soluble Form Has Also Been Detected
Alternative Protein Names	V-Set Domain-Containing T-Cell Activation Inhibitor 1 protein B7 Homolog 4 protein B7-H4 protein B7h.5 protein Immune Costimulatory Protein B7-H4 protein Protein B7s1 protein T-Cell Costimulatory Molecule B7x protein VTCN1 protein B7H4 protein UNQ659 protein PRO1291 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human B7-H4/VTCN1 protein (Recombinant) (C-His) (STJP000989)