BMP2 Blocking Peptide for STJ506124 peptide (STJ505861) STJ505861-250|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：BMP2 Blocking Peptide for STJ506124 peptide (STJ505861)
產品型號：STJ505861-250
產品廠商：ST john's laboratory
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簡單介紹：

BMP2 Blocking Peptide for STJ506124 peptide (STJ505861)

詳情介紹：

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	BMP2 Blocking Peptide for STJ506124 is synthetically produced from the 340-396 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	BMP2
Gene ID:	650
Uniprot ID:	BMP2_HUMAN
Immunogen Region:	340-396
Specificity:	This blocking peptide is recommended for use in combination with BMP2 antibody, STJ506124
Immunogen:	Synthetic peptide corresponding to amino acids within region 340-396 on human Bone morphogenetic Protein 2.

Tissue Specificity	Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Function	Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling.
Peptide Name	Bone Morphogenetic Protein 2 Bmp-2 Bone Morphogenetic Protein 2a Bmp-2a
Database Links	Reactome: R-HSA-201451 Reactome: R-HSA-2129379 Reactome: R-HSA-8878166 Reactome: R-HSA-8939902
Cellular Localisation	Secreted
Alternative Peptide Names	Bone Morphogenetic Protein 2 protein Bmp-2 protein Bone Morphogenetic Protein 2a protein Bmp-2a protein BMP2 protein BMP2A protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：BMP2 Blocking Peptide for STJ506124 peptide (STJ505861)