Anti-ABRAXAS1 antibody (350-400) {FITC} (STJ500024) STJ500024-100|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Anti-ABRAXAS1 antibody (350-400) {FITC} (STJ500024)

詳情介紹：

Host:	Rabbit
Applications:	ELISA/IP/WB
Reactivity:	Human/Monkey
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ABRAXAS1 (350-400) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.52-0.63 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	ABRAXAS1
Gene ID:	84142
Uniprot ID:	ABRX1_HUMAN
Immunogen Region:	350-400
Immunogen:	Synthetic peptide taken within amino acid region 350-400 on human BRCA1-A complex subunit Abraxas protein.

Post Translational Modifications	Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Ionizing radiation promotes rapid phosphorylation at Ser-404 and Ser-406 by ATM.this promotes recruitment of BRCA1 to sites of DNA damage.
Function	Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Protein Name	Brca1-A Complex Subunit Abraxas 1 Coiled-Coil Domain-Containing Protein 98 Protein Fam175a
Database Links	Reactome: R-HSA-5689901 Reactome: R-HSA-5693565 Reactome: R-HSA-5693571 Reactome: R-HSA-5693607 Reactome: R-HSA-69473
Cellular Localisation	Nucleus Localizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs)
Alternative Antibody Names	Anti-Brca1-A Complex Subunit Abraxas 1 antibody Anti-Coiled-Coil Domain-Containing Protein 98 antibody Anti-Protein Fam175a antibody Anti-ABRAXAS1 antibody Anti-ABRA1 antibody Anti-CCDC98 antibody Anti-FAM175A antibody Anti-UNQ496 antibody Anti-PRO1013 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ABRAXAS1 antibody (350-400) {FITC} (STJ500024)