產品詳情
簡單介紹：
Anti-ABRAXAS1 antibody (STJA0009665)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-BRCA1-A complex subunit Abraxas 1 is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABRAXAS1 |
| Gene ID: | 84142 |
| Uniprot ID: | ABRX1_HUMAN |
| Specificity: | This antibody detects endogenous levels of FAM175A at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human FAM175A |
| Function | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. |
| Protein Name | Brca1-A Complex Subunit Abraxas 1 Coiled-Coil Domain-Containing Protein 98 Protein Fam175a |
| Database Links | Reactome: R-HSA-5689901 Reactome: R-HSA-5693565 Reactome: R-HSA-5693571 Reactome: R-HSA-5693607 Reactome: R-HSA-69473 |
| Cellular Localisation | Nucleus Localizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs) |
| Alternative Antibody Names | Anti-Brca1-A Complex Subunit Abraxas 1 antibody Anti-Coiled-Coil Domain-Containing Protein 98 antibody Anti-Protein Fam175a antibody Anti-ABRAXAS1 antibody Anti-ABRA1 antibody Anti-CCDC98 antibody Anti-FAM175A antibody Anti-UNQ496 antibody Anti-PRO1013 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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