產品詳情
簡單介紹：
Anti-ABRAXAS2 antibody (STJA0009522)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-BRISC complex subunit Abraxas 2 is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABRAXAS2 |
| Gene ID: | 23172 |
| Uniprot ID: | ABRX2_HUMAN |
| Specificity: | This antibody detects endogenous levels of FAM175B at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human FAM175B |
| Function | Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm. Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1.deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage. |
| Protein Name | Brisc Complex Subunit Abraxas 2 Abraxas Brother Protein 1 Protein Fam175b |
| Database Links | Reactome: R-HSA-5689901 |
| Cellular Localisation | Cytoplasm Nucleus Cytoskeleton Spindle Pole A Minor Proportion Is Detected In The Nucleus Translocates Into The Nucleus In Response To Dna Damage Directly Binds To Microtubules And Is Detected At The Minus End Of K-Fibers Co-Localizes With Numa1 At Mitotic Spindle Poles |
| Alternative Antibody Names | Anti-Brisc Complex Subunit Abraxas 2 antibody Anti-Abraxas Brother Protein 1 antibody Anti-Protein Fam175b antibody Anti-ABRAXAS2 antibody Anti-ABRO1 antibody Anti-FAM175B antibody Anti-KIAA0157 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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