產品詳情
簡單介紹:
Anti-ACADVL antibody (1-140) (STJ110175)
詳情介紹:
Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-ACADVL (1-140) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | ACADVL |
Gene ID: | 37 |
Uniprot ID: | ACADV_HUMAN |
Immunogen Region: | 1-140 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human ACADVL (NP_000009.1). |
Immunogen Sequence: | MQAARMAASLGRQLLRLGGG SSRLTALLGQPRPGPARRPY AGGAAQLALDKSDSHPSDAL TRKKPAKAESKSFAVGMFKG QLTTDQVFPYPSVLNEEQTQ FLKELVEPVSRFFEEVNDPA KNDALEMVEETTWQGLKELG |
Tissue Specificity | Predominantly expressed in heart and skeletal muscle (at protein level). Also detected in kidney and liver (at protein level). |
Post Translational Modifications | S-nitrosylation at Cys-237 in liver improves catalytic efficiency. |
Function | Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains. |
Protein Name | Very Long-Chain Specific Acyl-Coa Dehydrogenase - Mitochondrial Vlcad |
Database Links | Reactome: R-HSA-381038 Reactome: R-HSA-77305 |
Cellular Localisation | Mitochondrion Inner Membrane Peripheral Membrane Protein Isoform 2: Mitochondrion Inner Membrane |
Alternative Antibody Names | Anti-Very Long-Chain Specific Acyl-Coa Dehydrogenase - Mitochondrial antibody Anti-Vlcad antibody Anti-ACADVL antibody Anti-VLCAD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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