產品詳情
簡單介紹：
Anti-ACER3 antibody (171-220 aa) (STJ91628)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Alkaline ceramidase 3 (171-220 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACER3 |
| Gene ID: | 55331 |
| Uniprot ID: | ACER3_HUMAN |
| Immunogen Region: | 171-220 aa |
| Specificity: | APHC Polyclonal Antibody detects endogenous levels of APHC protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human PHCA at the amino acid range 171-220 |
| Function | Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma. Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function. By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response. |
| Protein Name | Alkaline Ceramidase 3 Alkcdase 3 Alkaline Cdase 3 Alkaline Dihydroceramidase Sb89 Alkaline Phytoceramidase Aphc |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Golgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Alkaline Ceramidase 3 antibody Anti-Alkcdase 3 antibody Anti-Alkaline Cdase 3 antibody Anti-Alkaline Dihydroceramidase Sb89 antibody Anti-Alkaline Phytoceramidase antibody Anti-Aphc antibody Anti-ACER3 antibody Anti-APHC antibody Anti-PHCA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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