產品詳情
簡單介紹：
Anti-ABCA1 antibody (1170-1350) [S4627RM] (STJ11104627)
詳情介紹：
| Host: | Rabbit |
| Applications: | IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-Phospholipid-Transporting Atpase Abca1 (1170-1350) is suitable for use in Immunofluorescence research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S4627RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCA1 |
| Gene ID: | 19 |
| Uniprot ID: | ABCA1_HUMAN |
| Immunogen Region: | 1170-1350 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1170-1350 of human ABCA1 (NP_005493.2). |
| Immunogen Sequence: | DHESDTLTIDVSAISNLIRK HVSEARLVEDIGHELTYVLP YEAAKEGAFVELFHEIDDRL SDLGISSYGISETTLEEIFL KVAEESGVDAETSDGTLPAR RNRRAFGDKQSCLRPFTEDD AADPNDSDIDPESRETDLLS GMDGKGSYQVKGWKLTQQQF VALLWKRLLIARRSRKGFFA Q |
| Tissue Specificity | Widely expressed, but most abundant in macrophages. |
| Post Translational Modifications | Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylated by ZDHHC8. Palmitoylation is essential for localization to the plasma membrane. |
| Function | Catalyzes the translocations of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs. Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain. |
| Protein Name | Phospholipid-Transporting Atpase Abca1 Atp-Binding Cassette Sub-Family A Member 1 Atp-Binding Cassette Transporter 1 Abc-1 Atp-Binding Cassette 1 Cholesterol Efflux Regulatory Protein |
| Database Links | Reactome: R-HSA-1989781 Reactome: R-HSA-5682113 Reactome: R-HSA-8963896 Reactome: R-HSA-9029569 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Endosome |
| Alternative Antibody Names | Anti-Phospholipid-Transporting Atpase Abca1 antibody Anti-Atp-Binding Cassette Sub-Family A Member 1 antibody Anti-Atp-Binding Cassette Transporter 1 antibody Anti-Abc-1 antibody Anti-Atp-Binding Cassette 1 antibody Anti-Cholesterol Efflux Regulatory Protein antibody Anti-ABCA1 antibody Anti-ABC1 antibody Anti-CERP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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