Anti-ABCA2 antibody (140-350) (STJ119146) STJ119146|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-ABCA2 antibody (140-350) (STJ119146)
產品型號：STJ119146
產品廠商：ST john's laboratory
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Anti-ABCA2 antibody (140-350) (STJ119146)

詳情介紹：

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ABCA2 (140-350) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ABCA2
Gene ID:	20
Uniprot ID:	ABCA2_HUMAN
Immunogen Region:	140-350
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 140-350 of human ABCA2 (NP_001597.2).
Immunogen Sequence:	SHLDRSTVSSFSLDSVARNP QELWRFLTQNLSLPNSTAQA LLAARVDPPEVYHLLFGPSS ALDSQSGLHKGQEPWSRLGG NPLFRMEELLLAPALLEQLT CTPGSGELGRILTVPESQKG ALQGYRDAVCSGQAAARARR FSGLSAELRNQLDVAKVSQQ LGLDAPNGSDSSPQAPPPRR LQALLGDLLDAQKVLQDVDV LSALALLLPQG

Tissue Specificity	Isoform 3: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver. Isoform 4: Weakly expressed in brain and highly in peripheral blood leukocytes.
Post Translational Modifications	Methylated at Gln-271 by N6AMT1.
Function	Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation.
Protein Name	Atp-Binding Cassette Sub-Family A Member 2 Atp-Binding Cassette Transporter 2 Atp-Binding Cassette 2
Database Links	Reactome: R-HSA-1369062
Cellular Localisation	Endosome Membrane Multi-Pass Membrane Protein Lysosome Membrane Forms Discrete Punctate Intracellular Vesicles
Alternative Antibody Names	Anti-Atp-Binding Cassette Sub-Family A Member 2 antibody Anti-Atp-Binding Cassette Transporter 2 antibody Anti-Atp-Binding Cassette 2 antibody Anti-ABCA2 antibody Anti-ABC2 antibody Anti-KIAA1062 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ABCA2 antibody (140-350) (STJ119146)