产品详情

  • 产品名称：Anti-ACE2 antibody (N-Term) (STJ73762)

  • 产品型号：STJ73762-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ACE2 antibody (N-Term) (STJ73762)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB/IHC/FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-ACE2 (N-Term) is suitable for use in ELISA, Western Blot, Immunohistochemistry and Flow Cytometry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ACE2
Gene ID: 59272
Uniprot ID: ACE2_HUMAN
Immunogen Region: N-Term
Accession Number: NP_001358344.1
Immunogen Sequence: PROPRIETARY
Post Translational Modifications N-glycosylation on Asn-90 may limit SARS infectivity. Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1. Phosphorylated. Phosphorylation at Tyr-781 probably inhibits interaction with AP2M1 and enables interactions with proteins containing SH2 domains.
Function Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins (apelin-13, Pyr1apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency. In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity. (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. Isoform 2: Non-functional as a carboxypeptidase. Isoform 2: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2.
Protein Name Angiotensin-Converting Enzyme 2
Angiotensin-Converting Enzyme Homolog
Aceh
Angiotensin-Converting Enzyme-Related Carboxypeptidase
Ace-Related Carboxypeptidase
Metalloprotease Mprot15 Cleaved Into - Processed Angiotensin-Converting Enzyme 2
Database Links Reactome: R-HSA-2022377
Reactome: R-HSA-9678110
Reactome: R-HSA-9679191
Reactome: R-HSA-9694614
Reactome: R-HSA-9733458
Cellular Localisation Processed Angiotensin-Converting Enzyme 2: Secreted
Cell Membrane
Single-Pass Type I Membrane Protein
Cytoplasm
Cell Projection
Cilium
Apical Cell Membrane
Detected In Both Cell Membrane And Cytoplasm In Neurons
Isoform 2: Apical Cell Membrane
Alternative Antibody Names Anti-Angiotensin-Converting Enzyme 2 antibody
Anti-Angiotensin-Converting Enzyme Homolog antibody
Anti-Aceh antibody
Anti-Angiotensin-Converting Enzyme-Related Carboxypeptidase antibody
Anti-Ace-Related Carboxypeptidase antibody
Anti-Metalloprotease Mprot15 Cleaved Into - Processed Angiotensin-Converting Enzyme 2 antibody
Anti-ACE2 antibody
Anti-UNQ868 antibody
Anti-PRO1885 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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