产品详情

  • 产品名称：Human CRTAM/CD355 (A65V) protein (Recombinant) (C-His) (STJP002331)

  • 产品型号：STJP002331
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CRTAM/CD355 (A65V) protein (Recombinant) (C-His) (STJP002331)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CRTAM/CD355 (A65V)-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CRTAM
Gene ID: 56253
Uniprot ID: CRTAM_HUMAN
Immunogen Region: Ser18-Gly287
Immunogen: Recombinant Human CRTAM Protein is expressed from HEK293 cells with a His tag at the C-terminal.；It contains Ser18-Gly287.
Function Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation. Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity. Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production. By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells.
Protein Name Cytotoxic And Regulatory T-Cell Molecule
Class-I Mhc-Restricted T-Cell-Associated Molecule
Cd Antigen Cd355
Database Links Reactome: R-HSA-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
In A Subset Of Cd4+ T-Cells
Colocalizes With Scrib At The Immunological Synapse During The Late Phase Of T-Cell Activation
Alternative Protein Names Cytotoxic And Regulatory T-Cell Molecule protein
Class-I Mhc-Restricted T-Cell-Associated Molecule protein
Cd Antigen Cd355 protein
CRTAM protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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