产品详情

  • 产品名称：Ephrin Receptor A8 Blocking Peptide peptide (STJ504016)

  • 产品型号：STJ504016-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Ephrin Receptor A8 Blocking Peptide peptide (STJ504016)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Ephrin Receptor A8 Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: EPHA8
Gene ID: 2046
Uniprot ID: EPHA8_HUMAN
Immunogen: Synthetic peptide corresponding to unique amino acid sequences on human EphA R8 protein.
Function Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.
Peptide Name Ephrin Type-A Receptor 8
Eph- And Elk-Related Kinase
Eph-Like Kinase 3
Ek3
Hek3
Tyrosine-Protein Kinase Receptor Eek
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Early Endosome Membrane
Undergoes Clathrin-Mediated Endocytosis Upon Efna5-Binding And Is Targeted To Early Endosomes
Alternative Peptide Names Ephrin Type-A Receptor 8 protein
Eph- And Elk-Related Kinase protein
Eph-Like Kinase 3 protein
Ek3 protein
Hek3 protein
Tyrosine-Protein Kinase Receptor Eek protein
EPHA8 protein
EEK protein
HEK3 protein
KIAA1459 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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