产品详情

  • 产品名称：GPR56 Blocking Peptide peptide (STJ504157)

  • 产品型号：STJ504157-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
GPR56 Blocking Peptide peptide (STJ504157)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: GPR56 Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ADGRG1
Gene ID: 9289
Uniprot ID: AGRG1_HUMAN
Immunogen: Synthetic peptide taken from large extracellular loop of the human GPCR56 protein. Peptide was conjugated to Keyhole Limpet Haemocyanin (KLH).
Tissue Specificity Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells.
Post Translational Modifications Autoproteolytically cleaved into 2 fragments.the large extracellular N-terminal fragment (ADGRG1 NT) and the membrane-bound C-terminal fragment (ADGRG1 CT) predominantly remain associated and non-covalently linked. Shedding to yield the secreted ADGRG1 N-terminal fragment seems to involve metalloprotease(s). N-glycosylated. Contains sialic acid residues. Ubiquitinated. Undergoes polyubiquitination upon activation.
Function Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche. Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA. Plays an essential role in testis development. ADGRG1 N-terminal fragment: Plays a critical role in cancer progression by activating VEGFA production and angiogenesis through a signaling pathway mediated by PRKCA.
Peptide Name Adhesion G-Protein Coupled Receptor G1
G-Protein Coupled Receptor 56
Protein Tm7xn1 Cleaved Into - Adgrg1 N-Terminal Fragment
Adgrg1 Nt
Gpr56 N-Terminal Fragment
Gpr56 Nt
Gpr56(N
Gpr56 Extracellular Subunit
Gpr56 Subunit Alpha - Adgrg1 C-Terminal Fragment
Adgrg1 Ct
Gpr56 C-Terminal Fragment
Gpr56 Ct
Gpr56(C
Gpr56 Seven-Transmembrane Subunit
Gpr56 7tm
Gpr56 Subunit Beta
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Adgrg1 N-Terminal Fragment: Secreted
Adgrg1 C-Terminal Fragment: Membrane Raft
Interaction With Its Ligand Col3a1 Leads To The Release Of Adgrg1 Nt From The Membrane And Triggers The Association Of Adgrg1 Ct With Lipid Rafts
Alternative Peptide Names Adhesion G-Protein Coupled Receptor G1 protein
G-Protein Coupled Receptor 56 protein
Protein Tm7xn1 Cleaved Into - Adgrg1 N-Terminal Fragment protein
Adgrg1 Nt protein
Gpr56 N-Terminal Fragment protein
Gpr56 Nt protein
Gpr56(N protein
Gpr56 Extracellular Subunit protein
Gpr56 Subunit Alpha - Adgrg1 C-Terminal Fragment protein
Adgrg1 Ct protein
Gpr56 C-Terminal Fragment protein
Gpr56 Ct protein
Gpr56(C protein
Gpr56 Seven-Transmembrane Subunit protein
Gpr56 7tm protein
Gpr56 Subunit Beta protein
ADGRG1 protein
GPR56 protein
TM7LN4 protein
TM7XN1 protein
UNQ540 protein
PRO1083 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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