产品详情

  • 产品名称：Human JAM-2/VE-JAM/CD322 protein (Recombinant) (C-hFc&His) (STJP001199)

  • 产品型号：STJP001199
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human JAM-2/VE-JAM/CD322 protein (Recombinant) (C-hFc&His) (STJP001199)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human JAM-2/VE-JAM/CD322-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene Symbol: JAM2
Gene ID: 58494
Uniprot ID: JAM2_HUMAN
Immunogen: Recombinant Human JAM-2/VE-JAM/CD322 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe29-Asn236) of human JAM-B/VE-JAM (Accession #NP_067042.1) fused with a Fc, 6×His tag at the C-terminus.
Function Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium. Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation. Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons. During myogenesis, it is involved in myocyte fusion. May also play a role in angiogenesis.
Protein Name Junctional Adhesion Molecule B
Jam-B
Junctional Adhesion Molecule 2
Jam-2
Vascular Endothelial Junction-Associated Molecule
Ve-Jam
Cd Antigen Cd322
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-216083
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Tight Junction
Localized At Tight Junctions Of Both Epithelial And Endothelial Cells
Specifically Localized Within The Somatodendritic Compartment Of Neurons And Excluded From The Axon
Alternative Protein Names Junctional Adhesion Molecule B protein
Jam-B protein
Junctional Adhesion Molecule 2 protein
Jam-2 protein
Vascular Endothelial Junction-Associated Molecule protein
Ve-Jam protein
Cd Antigen Cd322 protein
JAM2 protein
C21orf43 protein
VEJAM protein
UNQ219 protein
PRO245 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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