产品详情

  • 产品名称：Human MUC-16/CA125 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002268)

  • 产品型号：STJP002268-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human MUC-16/CA125 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002268)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human MUC-16/CA125-C-His & Avi protein was developed from hek293 cells and has a target region of C-His & Avi. For use in research applications.
Conjugation: Biotin
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Endotoxin: Less than 1EU per Mu g by the LAL method.
Gene Symbol: MUC16
Gene ID: 94025
Uniprot ID: MUC16_HUMAN
Immunogen Region: Gly12660-Met12923
Immunogen: Recombinant Biotinylated Human CA125/MUC16 Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal.；It contains Gly12660-Met12923.
Post Translational Modifications Heavily O-glycosylated.expresses both type 1 and type 2 core glycans. Heavily N-glycosylated.expresses primarily high mannose and complex bisecting type N-linked glycans. May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
Function Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Protein Name Mucin-16
Muc-16
Ovarian Cancer-Related Tumor Marker Ca125
Ca-125
Ovarian Carcinoma Antigen Ca125
Database Links Reactome: R-HSA-5083625
Reactome: R-HSA-5083632
Reactome: R-HSA-5083636
Reactome: R-HSA-5621480
Reactome: R-HSA-913709
Reactome: R-HSA-977068
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Secreted
Extracellular Space
May Be Liberated Into The Extracellular Space Following The Phosphorylation Of The Intracellular C-Terminus Which Induces The Proteolytic Cleavage And Liberation Of The Extracellular Domain
Alternative Protein Names Mucin-16 protein
Muc-16 protein
Ovarian Cancer-Related Tumor Marker Ca125 protein
Ca-125 protein
Ovarian Carcinoma Antigen Ca125 protein
MUC16 protein
CA125 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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