产品详情

  • 产品名称：Anti-ALOX15 antibody (1-230) (STJ28944)

  • 产品型号：STJ28944
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ALOX15 antibody (1-230) (STJ28944)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ALOX15 (1-230) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ALOX15
Gene ID: 246
Uniprot ID: LOX15_HUMAN
Immunogen Region: 1-230
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human ALOX15 (NP_001131.3).
Immunogen Sequence: MGLYRIRVSTGASLYAGSNN QVQLWLVGQHGEAALGKRLW PARGKETELKVEVPEYLGPL LFVKLRKRHLLKDDAWFCNW ISVQGPGAGDEVRFPCYRWV EGNGVLSLPEGTGRTVGEDP QGLFQKHREEELEERRKLYR WGNWKDGLILNMAGAKLYDL PVDERFLEDKRVDFEVSLAK GLADLAIKDSLNVLTCWKDL DDFNRIFWCGQSKLAERVRD SWKEDALFGY
Tissue Specificity Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells.
Function Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE. It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties. Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets. Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides. Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1.10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function. It may also exert a negative effect on skeletal development by regulating bone mass through this pathway. As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver. Finally, it is also involved in the cellular response to IL13/interleukin-13.
Protein Name Polyunsaturated Fatty Acid Lipoxygenase Alox15
12/15-Lipoxygenase
Arachidonate 12-Lipoxygenase - Leukocyte-Type
12-Lox
Arachidonate 15-Lipoxygenase
15-Lox
15-Lox-1
Arachidonate Omega-6 Lipoxygenase
Hepoxilin A3 Synthase Alox15
Linoleate 13s-Lipoxygenase
Database Links Reactome: R-HSA-2142691
Reactome: R-HSA-2142712
Reactome: R-HSA-2142770
Reactome: R-HSA-6785807
Reactome: R-HSA-9018677
Reactome: R-HSA-9018681
Reactome: R-HSA-9018896
Reactome: R-HSA-9023661
Reactome: R-HSA-9025106
Reactome: R-HSA-9026286
Cellular Localisation Cytoplasm
Cytosol
Cell Membrane
Peripheral Membrane Protein
Lipid Droplet
Predominantly Cytosolic
Becomes Enriched At Membranes Upon Calcium Binding
Translocates From The Cytosol To The Plasma Membrane When Stimulated By Il13/Interleukin-13 And In Macrophages Binding Apoptotic Cells
Alternative Antibody Names Anti-Polyunsaturated Fatty Acid Lipoxygenase Alox15 antibody
Anti-12/15-Lipoxygenase antibody
Anti-Arachidonate 12-Lipoxygenase - Leukocyte-Type antibody
Anti-12-Lox antibody
Anti-Arachidonate 15-Lipoxygenase antibody
Anti-15-Lox antibody
Anti-15-Lox-1 antibody
Anti-Arachidonate Omega-6 Lipoxygenase antibody
Anti-Hepoxilin A3 Synthase Alox15 antibody
Anti-Linoleate 13s-Lipoxygenase antibody
Anti-ALOX15 antibody
Anti-LOG15 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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