产品详情

  • 产品名称：Anti-Alpha-Synuclein antibody (59-140) [S6MR] (STJ11103296)

  • 产品型号：STJ11103296
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-Alpha-Synuclein antibody (59-140) [S6MR] (STJ11103296)
详情介绍：
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Alpha-Synuclein (59-140) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S6MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SNCA
Gene ID: 6622
Uniprot ID: SYUA_HUMAN
Immunogen Region: 59-140
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 59-140 of human alpha-Synuclein (NP_000336.1).
Immunogen Sequence: TKEQVTNVGGAVVTGVTAVA QKTVEGAGSIAAATGFVKKD QLGKNEEGAPQEGILEDMPV DPDNEAYEMPSEEGYQDYEP EA
Tissue Specificity Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain.
Post Translational Modifications Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress. Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers. Ubiquitinated. The predominant conjugate is the diubiquitinated form. Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
Function Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
Protein Name Alpha-Synuclein
Non-A Beta Component Of Ad Amyloid
Non-A4 Component Of Amyloid Precursor
Nacp
Database Links Reactome: R-HSA-977225
Cellular Localisation Cytoplasm
Membrane
Nucleus
Synapse
Secreted
Cell Projection
Axon
Membrane-Bound In Dopaminergic Neurons
Expressed And Colocalized With Septin4 In Dopaminergic Axon Terminals
Especially At The Varicosities
Alternative Antibody Names Anti-Alpha-Synuclein antibody
Anti-Non-A Beta Component Of Ad Amyloid antibody
Anti-Non-A4 Component Of Amyloid Precursor antibody
Anti-Nacp antibody
Anti-SNCA antibody
Anti-NACP antibody
Anti-PARK1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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