产品详情

  • 产品名称：Anti-AMER1 antibody (STJA0008488)

  • 产品型号：STJA0008488
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AMER1 antibody (STJA0008488)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-APC membrane recruitment protein 1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AMER1
Gene ID: 139285
Uniprot ID: AMER1_HUMAN
Specificity: This antibody detects endogenous levels of WTX at Human, Mouse
Immunogen: Synthesized peptide derived from human WTX
Function Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.
Protein Name Apc Membrane Recruitment Protein 1
Amer1
Protein Fam123b
Wilms Tumor Gene On The X Chromosome Protein
Database Links Reactome: R-HSA-195253
Reactome: R-HSA-196299
Reactome: R-HSA-4641262
Reactome: R-HSA-5339716
Reactome: R-HSA-5358747
Reactome: R-HSA-5358749
Reactome: R-HSA-5358751
Reactome: R-HSA-5358752
Reactome: R-HSA-5467337
Reactome: R-HSA-5467340
Reactome: R-HSA-5467348
Reactome: R-HSA-8951664
Reactome: R-HSA-9755511
Cellular Localisation Cytoplasm
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Nucleus
Shuttles Between Nucleus And Cytoplasm
Detected In Nuclear Paraspeckles That Are Found Close To Splicing Speckles
Translocates To The Cell Membrane Following Binding To Ptdins(4
5)P2
Alternative Antibody Names Anti-Apc Membrane Recruitment Protein 1 antibody
Anti-Amer1 antibody
Anti-Protein Fam123b antibody
Anti-Wilms Tumor Gene On The X Chromosome Protein antibody
Anti-AMER1 antibody
Anti-FAM123B antibody
Anti-WTX antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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