产品详情

  • 产品名称：Anti-AMH antibody (R26-R451) [11303] (STJ400252)

  • 产品型号：STJ400252
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AMH antibody (R26-R451) [11303] (STJ400252)
详情介绍：
Host: Mouse
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-AMH (R26-R451) is suitable for use in ELISA research applications.
Clonality: Monoclonal
Clone ID: 11303
Conjugation: Unconjugated
Isotype: IgG1
Formulation: 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Purification: Greater than 95% purity
Concentration: 5.0 mg/ml (+/-10 %)
Storage Instruction: 12 months from manufacturing at 2–8°C. Temperature analysis:-70 °C, 21 days Not Determined (N/D)-20 °C, 14 days OK +4 °C, 14 days OK +35 °C, 14 days OK +45 °C, 7 days OK. Shelf life stability testing at 2–8 °C in the product buffer.
Association Rate Constant: 2.1 x 106 1/Ms
Determination Method: SPR analysis (ProteOn XPR36)
Immunoreactivity: 80–120 % compared to the reference sample in an FIA test
Gene Symbol: AMH
Gene ID: 268
Uniprot ID: MIS_HUMAN
Immunogen Region: R26-R451
Immunogen: Human anti-Müllerian hormone (AMH)
Tissue Specificity In ovaries, AMH is detected in granulosa cells of early growing follicles.
Post Translational Modifications Preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active non-covalent complex. Binding of the non-covalent complex to AMHR2 induces dissociation of the pro-region from the mature C-terminal dimer. The N-terminal portion of the protein, despite having no intrinsic activity, has the role of amplifying the activity of the C-terminus.
Function Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation. Also plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.
Protein Name Muellerian-Inhibiting Factor
Anti-Muellerian Hormone
Amh
Muellerian-Inhibiting Substance
Mis
Database Links Reactome: R-HSA-201451
Reactome: R-HSA-9690406
Cellular Localisation Secreted
Alternative Antibody Names Anti-Muellerian-Inhibiting Factor antibody
Anti-Anti-Muellerian Hormone antibody
Anti-Amh antibody
Anti-Muellerian-Inhibiting Substance antibody
Anti-Mis antibody
Anti-AMH antibody
Anti-MIF antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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