产品详情

  • 产品名称：Human ALOXE3 (Arachidonate Lipoxygenase 3) Sandwich ELISA Kit (STJE0007082)

  • 产品型号：STJE0007082
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human ALOXE3 (Arachidonate Lipoxygenase 3) Sandwich ELISA Kit (STJE0007082)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.114ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This ALOXE3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: ALOXE3
Gene ID: 59344
Uniprot ID: LOXE3_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Predominantly expressed in skin.
Post Translational Modifications
Function Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Also plays a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.
Protein Name Hydroperoxide Isomerase Aloxe3
Epidermis-Type Lipoxygenase 3
Epidermal Lox-3
E-Lox-3
Elox-3
Hydroperoxy Dehydratase Aloxe3
Hydroperoxy Icosatetraenoate Dehydratase
Hydroperoxy Icosatetraenoate Isomerase
Database Links Reactome: R-HSA-2142712
Cellular Localisation Cytoplasm
Alternative ELISA Names Hydroperoxide Isomerase Aloxe3 ELISA kit
Epidermis-Type Lipoxygenase 3 ELISA kit
Epidermal Lox-3 ELISA kit
E-Lox-3 ELISA kit
Elox-3 ELISA kit
Hydroperoxy Dehydratase Aloxe3 ELISA kit
Hydroperoxy Icosatetraenoate Dehydratase ELISA kit
Hydroperoxy Icosatetraenoate Isomerase ELISA kit
ALOXE3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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