产品详情

  • 产品名称：Human Neuropilin-1/NRP1/VEGF165R/CD304 protein (Recombinant) (C-His) (STJP002579)

  • 产品型号：STJP002579
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Neuropilin-1/NRP1/VEGF165R/CD304 protein (Recombinant) (C-His) (STJP002579)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Neuropilin-1/NRP1/VEGF165R/CD304-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human NRP1 Protein at 2 Mu g/mL (100 Mu L/well) can bind NRP1 Rabbit polyclonal antibody with a linear range of 1.9-98.96 ng/mL.2.Measured by its binding ability in a functional ELISA
Gene Symbol: NRP1
Gene ID: 8829
Uniprot ID: NRP1_HUMAN
Immunogen Region: Phe22-Lys644
Immunogen: Recombinant Human Neuropilin-1/NRP1/VEGF165R/CD304 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Phe22-Lys644) of human Neuropilin-1/NRP1 (Accession #NP_001019799) fused with a 6×His tag at the C-term
Function Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR. (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection. Isoform 2: Binds VEGF-165 and may inhibit its binding to cells. May induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
Protein Name Neuropilin-1
Vascular Endothelial Cell Growth Factor 165 Receptor
Cd Antigen Cd304
Database Links Reactome: R-HSA-194306
Reactome: R-HSA-376176
Reactome: R-HSA-399954
Reactome: R-HSA-399955
Reactome: R-HSA-399956
Reactome: R-HSA-445144
Reactome: R-HSA-447041
Reactome: R-HSA-9694614
Cellular Localisation Isoform 2: Secreted
Mitochondrion Membrane
Single-Pass Type I Membrane Protein
Cell Membrane
Cytoplasm
Alternative Protein Names Neuropilin-1 protein
Vascular Endothelial Cell Growth Factor 165 Receptor protein
Cd Antigen Cd304 protein
NRP1 protein
NRP protein
VEGF165R protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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