产品详情

  • 产品名称：Human CYP2C9 (Cytochrome P450 2C9) Sandwich ELISA Kit (STJE0008319)

  • 产品型号：STJE0008319
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CYP2C9 (Cytochrome P450 2C9) Sandwich ELISA Kit (STJE0008319)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.234ng/mL
Detection Limit: 0.625-40ng/mL
Short Description: This CYP2C9 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: CYP2C9
Gene ID: 1559
Uniprot ID: CP2C9_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2. Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol. Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Protein Name Cytochrome P450 2c9
(R-Limonene 6-Monooxygenase
(S-Limonene 6-Monooxygenase
(S-Limonene 7-Monooxygenase
Cypiic9
Cholesterol 25-Hydroxylase
Cytochrome P-450mp
Cytochrome P450 Mp-4
Cytochrome P450 Mp-8
Cytochrome P450 Pb-1
S-Mephenytoin 4-Hydroxylase
Database Links Reactome: R-HSA-211981
Reactome: R-HSA-211999
Reactome: R-HSA-2142670
Reactome: R-HSA-2142816
Reactome: R-HSA-9027307
Reactome: R-HSA-9749641
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Microsome Membrane
Alternative ELISA Names Cytochrome P450 2c9 ELISA kit
(R-Limonene 6-Monooxygenase ELISA kit
(S-Limonene 6-Monooxygenase ELISA kit
(S-Limonene 7-Monooxygenase ELISA kit
Cypiic9 ELISA kit
Cholesterol 25-Hydroxylase ELISA kit
Cytochrome P-450mp ELISA kit
Cytochrome P450 Mp-4 ELISA kit
Cytochrome P450 Mp-8 ELISA kit
Cytochrome P450 Pb-1 ELISA kit
S-Mephenytoin 4-Hydroxylase ELISA kit
CYP2C9 ELISA kit
CYP2C10 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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