产品详情

  • 产品名称：PODXL Positive Control for STJ502578 peptide (STJ505280)

  • 产品型号：STJ505280-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
PODXL Positive Control for STJ502578 peptide (STJ505280)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: PODXL Positive Control for STJ502578 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PODXL
Gene ID: 5420
Uniprot ID: PODXL_HUMAN
Specificity: This is positive control is recommended for use in combination with PODXL antibody STJ502578.
Tissue Specificity Glomerular epithelium cell (podocyte).
Post Translational Modifications N- and O-linked glycosylated. Sialoglycoprotein.
Function Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
Peptide Name Podocalyxin
Gctm-2 Antigen
Gp200
Podocalyxin-Like Protein 1
Pc
Pclp-1
Cellular Localisation Apical Cell Membrane
Cell Projection
Lamellipodsium
Filopodium
Ruffle
Microvillus
Membrane Raft
Membrane
Single-Pass Type I Membrane Protein
In Single Attached Epithelial Cells Is Restricted To A Preapical Pole On The Free Plasma Membrane Whereas Other Apical And Basolateral Proteins Are Not Yet Polarized
Colocalizes With Nherf2 At The Apical Plasma Membrane During Epithelial Polarization
Colocalizes With Nherf1 At The Trans-Golgi Network (Transiently) And At The Apical Plasma Membrane
Its Association With The Membrane Raft Is Transient
Colocalizes With Actin Filaments
Ezr And Nherf1 In A Punctate Pattern At The Apical Cell Surface Where Microvilli Form
Colocalizes With Ezr And Nherf2 At The Apical Cell Membrane Of Glomerular Epithelium Cells
Forms Granular
Punctuated Pattern
Forming Patches
Preferentially Adopting A Polar Distribution
Located On The Migrating Poles Of The Cell Or Forming Clusters Along The Terminal Ends Of Filipodsia Establishing Contact With The Endothelial Cells
Colocalizes With The Submembrane Actin Of Lamellipodsia
Particularly Associated With Ruffles
Colocalizes With Vinculin At Protrusions Of Cells
Colocalizes With Itgb1
Colocalizes With Pard3
Prkci
Exoc5
Ocln
Rab11a And Rab8a In Apical Membrane Initiation Sites (Amis) During The Generation Of Apical Surface And Luminogenesis
Alternative Peptide Names Podocalyxin protein
Gctm-2 Antigen protein
Gp200 protein
Podocalyxin-Like Protein 1 protein
Pc protein
Pclp-1 protein
PODXL protein
PCLP protein
PCLP1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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