产品详情

  • 产品名称：Anti-BMP1 antibody (131-180 aa) (STJ98798)

  • 产品型号：STJ98798
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BMP1 antibody (131-180 aa) (STJ98798)
详情介绍：
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Bone morphogenetic protein 1 (131-180 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-200
ELISA 1:10000-20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BMP1
Gene ID: 649
Uniprot ID: BMP1_HUMAN
Immunogen Region: 131-180 aa
Specificity: The antibody detects endogenous BMP-1
Immunogen: Synthetic peptide from the human protein at the amino acid range 131-180
Post Translational Modifications Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion.
Function Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation. Isoform BMP1-3: Plays an important role in bone repair by acting as a coactivator of BMP7.
Protein Name Bone Morphogenetic Protein 1
Bmp-1
Mammalian Tolloid Protein
Mtld
Procollagen C-Proteinase
Pcp
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-1650814
Reactome: R-HSA-2214320
Reactome: R-HSA-2243919
Reactome: R-HSA-8963896 P13497-3
Cellular Localisation Golgi Apparatus
Trans-Golgi Network
Secreted
Extracellular Space
Extracellular Matrix
Co-Localizes With Postn In The Golgi
Isoform Bmp1-3: Secreted
Alternative Antibody Names Anti-Bone Morphogenetic Protein 1 antibody
Anti-Bmp-1 antibody
Anti-Mammalian Tolloid Protein antibody
Anti-Mtld antibody
Anti-Procollagen C-Proteinase antibody
Anti-Pcp antibody
Anti-BMP1 antibody
Anti-PCOLC antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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