产品详情

  • 产品名称：Anti-CASTOR1 antibody (1-329) (STJ11103420)

  • 产品型号：STJ11103420
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CASTOR1 antibody (1-329) (STJ11103420)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CASTOR1 (1-329) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CASTOR1
Gene ID: 652968
Uniprot ID: CAST1_HUMAN
Immunogen Region: 1-329
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-329 of human CASTOR1 (NP_001032755.1).
Immunogen Sequence: MELHILEHRVRVLSVARPGL WLYTHPLIKLLFLPRRSRCK FFSLTETPEDYTLMVDEEGF KELPPSEFLQVAEATWLVLN VSSHSGAAVQAAGVTKIARS VIAPLAEHHVSVLMLSTYQT DFILVREQDLSVVIHTLAQE FDIYREVGGEPVPVTRDDSS NGFPRTQHGPSPTVHPIQSP QNRFCVLTLDPETLPAIATT LIDVLFYSHSTPKEAASSSP EPSSITFFAFSLIEGYISI
Tissue Specificity Widely expressed.
Post Translational Modifications Phosphorylation at Ser-14 by AKT1, promoting the interaction between CASTOR1 and RNF167. Ubiquitinated by RNF167 via 'Lys-29'-polyubiquitination, leading to its degradation, releasing the GATOR2 complex. Ubiquitination by RNF167 is promoted by phosphorylation at Ser-14 by AKT1.
Function Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
Protein Name Cytosolic Arginine Sensor For Mtorc1 Subunit 1
Cellular Arginine Sensor For Mtorc1 Protein 1
Gats-Like Protein 3
Database Links Reactome: R-HSA-9639288
Cellular Localisation Cytoplasm
Cytosol
Alternative Antibody Names Anti-Cytosolic Arginine Sensor For Mtorc1 Subunit 1 antibody
Anti-Cellular Arginine Sensor For Mtorc1 Protein 1 antibody
Anti-Gats-Like Protein 3 antibody
Anti-CASTOR1 antibody
Anti-GATSL3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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